ABSTRACT
Objective: To investigate the change on phacoemulsification combined with intraocular lens implantation on inflammatory factors IL-2, IL-6, hs-CRP, TNF- alpha; oxidative stress response indexes MDA, CAT, SOD, GSH-Px; peripheral blood hemorheologic index WHV, WMV,PV, PCV, FIB in diabetic cataract patients. Study Design: An observational study. Place and Duration of Study: Department of Ophthalmology, the Second Hospital of Shandong University, Jinan, China, from January 2015 to July 2017
Methodology: One hundred anf fifty-two diabetic cataract patients [160 eyes] were randomly divided into observation group and control group, each with 76 cases [80 eyes]. The control group was treated with conventional therapy, while the observation group was treated with phacoemulsification combined with intraocular lens implantation on the basis of conventional treatment. After one month of treatment, the patients were tested for IL-2, IL-6, hs-CRP, TNF- alpha, MDA, CAT, SOD, GSH-Px, WHV, WMV, PV, PCV, FIB
Results: After one month of treatment, the levels of IL-2, IL-6, hs-CRP and TNF- alpha were lower in the observation group [p<0.001]; the levels of SOD, GSH-Px and CAT were higher in the observation group [p<0.001], while MDA level was higher in the control group [p<0.001]; the levels of WHV, WMV, PV were lower in the observation group [p<0.001], and there was no significant difference in the levels of PCV and FIB between the two groups [p = 0.794 and 0.838, respectively]
Conclusion: Phacoemulsification combined with intraocular lens implantation can improve the level of aqueous inflammatory factors and oxidative stress response indexes in diabetic cataract patients and improve their level of hemorheological indexest
ABSTRACT
Objective: To investigate the change on phacoemulsification combined with intraocular lens implantation on inflammatory factors IL-2, IL-6, hs-CRP,TNF-Alpha; oxidative stress response indexes MDA, CAT, SOD, GSH-Px; peripheral blood hemorheologic index WHV, WMV,PV, PCV, FIB in diabetic cataract patients
Study Design: An observational study
Place and Duration of Study: Department of Ophthalmology, the Second Hospital of Shandong University, Jinan, China, from January 2015 to July 2017
Methodology: One hundred anf fifty-two diabetic cataract patients [160 eyes] were randomly divided into observation group and control group, each with 76 cases [80 eyes]. The control group was treated with conventional therapy, while the observation group was treated with phacoemulsification combined with intraocular lens implantation on the basis of conventional treatment. After one month of treatment, the patients were tested for IL-2, IL-6, hs-CRP, TNF-Alpha, MDA, CAT, SOD, GSH-Px, WHV, WMV, PV, PCV, FIB
Results: After one month of treatment, the levels of IL-2, IL-6, hs-CRP and TNF-Alpha were lower in the observation group [p <0.001]; the levels of SOD, GSH-Px and CAT were higher in the observation group [p <0.001], while MDA level was higher in the control group [p <0.001]; the levels of WHV, WMV, PV were lower in the observation group [p <0.001], and there was no significant difference in the levels of PCV and FIB between the two groups [p = 0.794 and 0.838, respectively]
Conclusion: Phacoemulsification combined with intraocular lens implantation can improve the level of aqueous inflammatory factors and oxidative stress response indexes in diabetic cataract patients and improve their level of hemorheological indexest